True brain-boosting nootropics must have very few side effects and extremely low toxicity, so in other words by definition nootropics are safe. Many cognitive enhancers have been found to be relatively safe in clinical trials.
Two rules to live by are to choose the right nootropic that has high-quality ingredients and well-designed formulas, plus take it the correct way. Meaning using established stacking strategies and following manufacturer’s directions.
The decision of whether or not to take any particular drug or dietary supplement should be made based on consultation with a doctor, through independent research, and personal risk tolerance. Nootropics are taken at your own and are not intended to treat or diagnose any diseases.